[1]喻理德,徐其雄,王 星.莫西沙星侧链合成方法改进[J].江西师范大学学报(自然科学版),2017,(05):507-509.
 YU Lide,XU Qixiong,WANG Xing.The Improved Synthesis of Moxifloxacin Side Chain[J].Journal of Jiangxi Normal University:Natural Science Edition,2017,(05):507-509.
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莫西沙星侧链合成方法改进()
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《江西师范大学学报》(自然科学版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2017年05期
页码:
507-509
栏目:
出版日期:
2017-11-01

文章信息/Info

Title:
The Improved Synthesis of Moxifloxacin Side Chain
作者:
喻理德徐其雄王 星
1.江西中医药大学药物设计合成中心,江西 南昌 330004; 2.南昌森腾医药生物科技有限公司,江西 南 昌 330012
Author(s):
YU LideXU QixiongWANG Xing
1.Drug Design & Synthesis Center,Jiangxi Chinese Medicine University,Nanchang Jiangxi 330004,China; 2.Nanchang Certain Biological Technology Company Limited,Nanchang Jiangxi 330004,China
关键词:
莫西沙星侧链 合成方法 改进
Keywords:
moxifloxacin side chain synthesis improvement
分类号:
TQ 463.53
文献标志码:
A
摘要:
以2,3-吡啶二羧酸为原料,经过环合、催化氢化、拆分、消旋、化学还原、脱苄基等反应步骤,合成得到莫西沙星侧链.该合成线路比现有常规合成路线污染小,收率较高.
Abstract:
Moxifloxacin side chain is synthesized from 2,3-pyridinedicarboxylic acid as raw material,through cyclization,catalytic hydrogenation,resolution,racemization chemical reduction,debenzylation.Compared with the existed synthesis routes,the improved synthesis has advantages of small pollution and high yield.

参考文献/References:

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[9] 喻理德.受体酪氨基酸激酶抑制剂的合成 [J].江西师范大学学报:自然科学版,2013,37(2):152-154.

备注/Memo

备注/Memo:
收稿日期:2016-12-06基金项目:国家自然科学基金(81360629)和江西中医药大学自然科学基金(2012ZR030)资助项目.作者简介:喻理德(1966-),男,江西南昌人,副教授,主要从事药物及中间体合成研究.E-mail:414872873@qq.com
更新日期/Last Update: 1900-01-01