[1]孙晓可,杨 飒,孟祥波,等.不同配比18α-与18β-甘草酸对酒精性肝损伤大鼠肝功能的影响[J].江西师范大学学报(自然科学版),2018,(02):166-170.[doi:10.16357/j.cnki.issn1000-5862.2018.02.09]
　SUN Xiaoke,YANG Sa,MENG Xiangbo,et al.The Effect of Different Proportion of 18α-,18β-Glycyrrhizic Acid on the Liver Function in Alcoholic Liver Disease Rat[J].Journal of Jiangxi Normal University:Natural Science Edition,2018,(02):166-170.[doi:10.16357/j.cnki.issn1000-5862.2018.02.09]
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不同配比18α-与18β-甘草酸对酒精性肝损伤大鼠肝功能的影响()
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《江西师范大学学报》（自然科学版）[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2018年02期
页码:
166-170
栏目:
化学与生命科学
出版日期:
2018-04-20

文章信息/Info

Title:
The Effect of Different Proportion of 18α-,18β-Glycyrrhizic Acid on the Liver Function in Alcoholic Liver Disease Rat
文章编号:
1000-5862(2018)02-0166-05
作者:
孙晓可; 杨 飒; 孟祥波; 周程艳; 赵燕燕*
河北大学药学院,河北省药物质量分析控制重点实验室,河北 保定 071002
Author(s):
SUN Xiaoke; YANG Sa; MENG Xiangbo; ZHOU Chengyan; ZHAO Yanyan*
College of Pharmaceutical Science,Key Laboratory of Pharmaceutical Quality Control of Hebei Province,Hebei University,Baoding Hebei 071002,China
关键词:
酒精性肝损伤;  肝功能;  不同配比;  18α-甘草酸和18β-甘草酸
Keywords:
alcoholic liver disease;  liver function;  different proportion;  18α-glycyrrhizic acid and 18β-glycyrrhizic acid
分类号:
R 975.5
DOI:
10.16357/j.cnki.issn1000-5862.2018.02.09
文献标志码:
A
摘要:
探讨不同配比18α-与18β-甘草酸(Gly)对大鼠酒精性肝损伤的影响.健康SD大鼠,雄性,随机分组,每组10只,即正常对照组(生理盐水)、模型对照组(生理盐水)、阳性药物对照组(水飞蓟宾)、7个给药组(18α-Gly与18β-Gly不同配比组,配比为10:0,8:2,6:4,5:5,4:6,2:8,0:10).给药4周后,检测不同组对血清酶、血清蛋白、总胆红素、胆汁酸及血糖调控的影响.结果显示:18α-Gly与18β-Gly各个配比均能降低血清酶ALT、AST、γ-GT、LDH活性,随着18β-Gly比例增加作用增强,当18α-Gly与18β-Gly配比小于4:6时,对缓解酒精性肝损伤和心肌损伤效果更佳; 当配比大于8:2时,对酒精性肝损伤大鼠血清蛋白水平的改善作用更加显著.当配比小于4:6时,明显降低TBIL和TBA水平,显著改善酒精性肝损伤大鼠对血糖的调控能力.研究结果为新药研发和临床治疗的制剂选择提供依据.
Abstract:
The objective is that investigating protective effects of different proportion of 18α- and 18β- glycyrrhizic acid(Gly)on alcoholic liver injury in rats.Healthy male rats are randomly divided into equally ten groups,respectively normal control group(saline),model group(saline),positive drug control group(silymarin),7 given drug groups(different ratios of 18α-Gly and 18β-Gly group,and ratios are 10:0,8:2,6:4,5:5,4:6,2:8,0:10).At the fourth week,blood are collected to determine serum ferment and proteins,total bilirubin and acid bile.Blood glucose is measured.The results show that different proportions of 18α- and 18β-glycyrrhizic acid all effectively reduced ALT,AST,γ-GT and LDH activity.The alcoholic liver injury and myocardial injury can be better improved when the ratio is less than 4:6.And the serum protein level in alcoholis liver injury rat is improved when the ratio is greater then 8:2.The level of TBIL and TBA.And is attenuated when the ratio is less than 4:6.And the proportion is less then 4:6 that obviously improves the ability of regulating the blood glucose of rats with alcoholic liver injury.It can be applied to selection of new drug research and clinical treatment with a basic experiment data.

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备注/Memo

备注/Memo:
收稿日期:2017-07-05
基金项目:河北省自然科学基金(H2013201203)和河北大学医学学科专项资金(2014A1003)资助项目.
通信作者:赵燕燕(1960-),女,天津市人,教授,博士,主要从事药学,以及将现代分离技术用于临床、药学、食品、环境等方面的研究.E-mail:zhaoyany606@163.com
更新日期/Last Update: 2018-04-20