[1]谢兵,庞向东,万邦江,等.酸性铬蓝K分光光度法测定盐酸西布曲明的含量[J].江西师范大学学报(自然科学版),2012,(01):16-20.
 XIE Bing,PANG Xiang-dong,WAN Bang-jiang,et al.Spectrophotometric Method for Determination of the Content of Sibutramine Hydrochloride with Acid Chrome Blue K[J].,2012,(01):16-20.
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酸性铬蓝K分光光度法测定盐酸西布曲明的含量()
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《江西师范大学学报》(自然科学版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2012年01期
页码:
16-20
栏目:
出版日期:
2012-01-01

文章信息/Info

Title:
Spectrophotometric Method for Determination of the Content of Sibutramine Hydrochloride with Acid Chrome Blue K
作者:
谢兵;庞向东;万邦江;甘湘庆;秦宗会
长江师范学院化学化工学院, 重庆 408100
Author(s):
XIE Bing PANG Xiang-dong WAN Bang-jiang GAN Xiang-qing QIN Zong-hui
关键词:
酸性铬蓝K 分光光度法 盐酸西布曲明
Keywords:
acid chrome blue K spectrophotometry sibutramine hydrochloride
分类号:
O 657.3
文献标志码:
A
摘要:
在pH 值为7.50的Britton-Robinson缓冲介质中, 盐酸西布曲明与酸性铬蓝K反应, 形成离子缔合物, 溶液颜色发生明显改变, 最大吸收波长位于564 nm, 同时在652 nm处形成负吸收. 在负吸收处, 线性关系良好, 从而建立测定盐酸西布曲明的分光光度法. 在652 nm处, 盐酸西布曲明的浓度在0~4.80×10–6 mol/L范围内遵守比尔定律, 表观摩尔吸光系数为3.35×104 L/(mol?cm), 检出限为1.66×10–7 mol/L. 该方法具有较高的灵敏度和良好的选择性, 用于合成样及尿样中盐酸西布曲明的测定, 结果满意.
Abstract:
In Britton-Robinson buffer solution with pH 7.70, sibutramine hydrochloride reacts with acid chrome blue K to form ion association complex, resulting that the solution color changes significantly. The maximum absorption wavelength and maximum fading wavelength are at 564 nm and 652 nm respectively. The fading colour intensity is also proportional to the concentration of sibutramine hydrochloride, Based on this the determination method of sibutramine hydrochloride was established. At the fading wavelength, with the concentration range of 0-4.80×10–6 mol/L the concentrations of sibutramine hydrochloride comply with the Beer's law, the apparent molar absorptivity is 3.35×104 L/(mol?cm) and the detection limit is 1.66×10–7 mol/L. The method has high sensitivity and good selectivity. It was successfully used for the determination of content of sibutramine hydrochloride complex samples and human urine, with satisfactory results.

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更新日期/Last Update: 1900-01-01