[1]史娟.K_3[Fe(CN)_6]作为氰源合成5,7-二羟基-8-氰甲基黄酮的正交试验研究[J].江西师范大学学报(自然科学版),2014,(02):191-195.
 SHI Juan.The Synthesis of 5,7-Dihydroxyl-8-Cyanomethyflavone by Orthogonal Design with Potassium Hexacyanoferrate (Ⅲ)[J].,2014,(02):191-195.
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K_3[Fe(CN)_6]作为氰源合成5,7-二羟基-8-氰甲基黄酮的正交试验研究()
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《江西师范大学学报》(自然科学版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2014年02期
页码:
191-195
栏目:
出版日期:
2014-04-30

文章信息/Info

Title:
The Synthesis of 5,7-Dihydroxyl-8-Cyanomethyflavone by Orthogonal Design with Potassium Hexacyanoferrate (Ⅲ)
作者:
史娟
陕西理工学院化学与环境科学学院,陕西汉中,723000
Author(s):
SHI Juan
关键词:
57-二羟基-8-氯甲基黄酮57-二羟基-8-氰甲基黄酮氰基化
Keywords:
57-dihydroxyl-8-cyanomethyflavone57-dihydroxy-8-chloromethylflavonecyanomethylation
分类号:
TQ464
文献标志码:
A
摘要:
5,7-二羟基-8-氰甲基黄酮是黄酮醋酸类化合物中间体.以5,7-二羟基黄酮为原料,经氯甲基化反应得到5,7-二羟基-8-氯甲基黄酮.在此基础上,在碱性条件下,以无毒、廉价的K3[Fe(CN)6]为氰源,Cu(OAc)2为催化剂,合成5,7-二羟基-8-氰甲基黄酮.探讨了反应温度、催化剂与原料摩尔比、K3[Fe(CN)6]与原料摩尔比及碱与原料摩尔比等因素对氰基化反应的影响,从而确定氰基化反应的最佳条件是:反应温度为100℃,催化剂Cu(OAc)2与原料的摩尔比为0.004∶1,K3[Fe(CN)6]与原料的摩尔比为0.1∶1,Na2CO3与原料的摩尔比为1.5∶1,在此条件下反应收率为72.8;.
Abstract:
5,7-dihydroxyl-8-cyanomethyflavone is the intermediate product of substituted flavone-8-acetic acids.5,7-dihydroxy-8-chloromethylflavone was synthesized by chloromethylation of the corresponding 5,7-dihydroxyflavone.Based on this reaction,the production of cyanomethylation was synthesized by 5,7-dihydroxy-8-chloromethylflavone with K3[Fe(CN)6] under catalyzed by Cu(OAc)2 and Na2CO3.The effects of reaction temperature,the molar ratio of catalyst and the raw materials,the molar ratio of potassium ferricyanide and the raw materials,the molar ratio of bases and the raw materials were discussed.The optimum reaction conditions is,reaction temperature of 100 ℃,the molar ratio of catalyst and the raw materials 0.004:1,the molar ratio of potassium ferricyanide and the raw materials 0.1:1,the molar ratio of bases and the raw materials 1.5:1,a good yield(72.8%)was obtained.

参考文献/References:

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备注/Memo

备注/Memo:
国家自然科学基金(21373132);陕西省教育厅2012年科学研究计划(12JK0633)
更新日期/Last Update: 1900-01-01