[1]杨彩玲,韩金红,王伟新,等.盐酸埃克替尼对ACC-M细胞MMP-2、E-cadherin蛋白表达的影响[J].江西师范大学学报(自然科学版),2014,(04):367-369.
 YANG Cai-ling,HAN Jin-hong,WANG Wei-xin,et al.Influence of Icotinib Hydrochloride uPon the Protein ExPression of ACC-M Cells MMP-2 and E-cadherin[J].,2014,(04):367-369.
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盐酸埃克替尼对ACC-M细胞MMP-2、E-cadherin蛋白表达的影响()
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《江西师范大学学报》(自然科学版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2014年04期
页码:
367-369
栏目:
出版日期:
2014-08-31

文章信息/Info

Title:
Influence of Icotinib Hydrochloride uPon the Protein ExPression of ACC-M Cells MMP-2 and E-cadherin
作者:
杨彩玲;韩金红;王伟新;崔卫刚
新乡医学院第一附属医院口腔外科,河南 卫辉,453100;新乡医学院基础医学院,河南 新乡,453003
Author(s):
YANG Cai-ling;HAN Jin-hong;WANG Wei-xin;CUI Wei-gang
关键词:
盐酸埃克替尼ACC-M 细胞MMP-2E-cadherin
Keywords:
icotinib hydrochlorideACC-M cellsMMP-2E-cadherin
分类号:
R734.2
文献标志码:
A
摘要:
盐酸埃克替尼是一种表皮生长因子受体酪氨酸激酶抑制剂,利用免疫细胞化学方法和间接免疫荧光联合流式细胞技术,检测它在体外对人涎腺腺样囊性癌细胞株(ACC-M)MMP-2、E-cadherin 蛋白表达的影响。结果表明:盐酸埃克替尼可降低 MMP-2蛋白表达,增加 E-cadherin 蛋白表达,可抑制人涎腺腺样囊性癌 ACC-M 细胞的浸润、转移。
Abstract:
Icotinib hydrochloride is a kind of epidermal growth factor receptor tyrosine kinase inhibitor,whose influ-ence upon the protein expression of ACC-M cells MMP-2 and E-cadherin can be tested by way of immunocytochem-istry and the technique of indirect immunofluorescence together with flow cytometry. The results show that icotinib hydrochloride can reduce the protein expression of MMP-2,but increase that of E-cadherin,thus it can be used to restrain the infiltration and metastasis of ACC-M cells.

参考文献/References:

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备注/Memo

备注/Memo:
新乡医学院高学历人才基金(GXLZZ2008-09)
更新日期/Last Update: 1900-01-01