[1]邓伟,刘晓玲,毛雪春,等.聚乙二醇负载苯磺酸催化Biginelli反应合成3,4-二氢嘧啶-2-酮衍生物的研究[J].江西师范大学学报(自然科学版),2015,(01):88-93.
 DENG Wei,LIU Xiaoling,MAO Xuechun,et al.The Biginelli Reaction Catalyzed by Poly(Ethylene Glycol)-Supported Benzene Sulfonic Acid for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-One Derivatives[J].,2015,(01):88-93.
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聚乙二醇负载苯磺酸催化Biginelli反应合成3,4-二氢嘧啶-2-酮衍生物的研究()
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《江西师范大学学报》(自然科学版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2015年01期
页码:
88-93
栏目:
出版日期:
2015-02-10

文章信息/Info

Title:
The Biginelli Reaction Catalyzed by Poly(Ethylene Glycol)-Supported Benzene Sulfonic Acid for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-One Derivatives
作者:
邓伟;刘晓玲;毛雪春;廖维林
1.江西师范大学化学化工学院,江西 南昌 330022; 2.江西师范大学国家单糖化学合成工程技术研究中心,江西 南昌 330022
Author(s):
DENG WeiLIU XiaolingMAO XuechunLIAO Weilin
关键词:
Biginelli反应 34-二氢嘧啶-2-酮衍生物 聚乙二醇负载的苯磺酸催化剂 合成
Keywords:
Biginelli reaction 34-dihydropyrimidin-2(1H)-one derivatives poly(ethylene glycol)-supported benzene sulfonic acid catalyst synthesis
分类号:
O 625
文献标志码:
A
摘要:
在聚乙二醇负载的苯磺酸催化作用下,由醛、乙酰乙酸乙酯(或乙酰丙酮)、脲(或硫脲)3组份经Biginelli 反应“一锅法”合成了系列3,4-二氢嘧啶-2-酮衍生物.该方法反应条件温和、反应时间短、产率高,并且催化剂具有可重复使用的优点.
Abstract:
3,4-Dihydropyrimidin-2(1H)-ones and their derivatives were synthesized in high yields by one-pot three-component Beginelli condensation reactions of aldehydes,ethyl acetoacetate or acetylacetone,urea or thiourea in the presence of catalytic amounts of poly(ethylene glycol)-supported benzene sulfonic acid in ethanol at reflux temperature.This method has such advantages as high yield,short reaction time and simple manipulation.The catalyst is also found to exhibit reusable activity.

参考文献/References:

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备注/Memo

备注/Memo:
国家自然科学基金(21062007);江西省教育厅科研基金(GJJ11380);国家单糖化学合成工程技术研究中心开放基金课题(GJDTZX-KF-201414)
更新日期/Last Update: 1900-01-01