[1]刘福炎,林 常,王 博.一锅法合成α-酮酰胺[J].江西师范大学学报(自然科学版),2017,(02):145-159.
 LIU Fuyan,LIN Chang,WANG Bo.One Pot Synthesis of α-Ketoamides[J].,2017,(02):145-159.
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一锅法合成α-酮酰胺()
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《江西师范大学学报》(自然科学版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2017年02期
页码:
145-159
栏目:
出版日期:
2017-03-01

文章信息/Info

Title:
One Pot Synthesis of α-Ketoamides
作者:
刘福炎林 常王 博
海南大学材料与化工学院,海南 海口 570228
Author(s):
LIU FuyanLIN ChangWANG Bo
College of Materials and Chemical Engineering,Hainan University,Haikou Hainan 570228,China
关键词:
α-酮酰胺 芳基甲基酮 碘化亚铜 过氧化叔丁醇
Keywords:
α-ketoamides aryl methyl ketones copper(I)iodide tert-butyl hydroperoxide
分类号:
O 621.3
文献标志码:
A
摘要:
介绍了一种以芳基甲基酮为原料以碘化亚铜为催化剂和过氧化叔丁醇为氧化剂的一锅法合成α-酮酰胺的简便方法.该方法反应条件温和,产率高,有较好的原子经济性.在3倍的过氧化叔丁醇下,绝大部分的芳基甲基酮和胺类反应都能很好地转化成α-酮酰胺.通过柱层析对粗产物进行纯化以及采用1H NMR和13C NMR对产物结构进行表征,α-酮酰胺在有机合成上具有潜在应用价值.
Abstract:
A one-pot synthetic protocol of α-ketoamides from aryl methyl ketones using copper(I)iodide as catalyst and tert-butyl hydroperoxide as oxidant is reported in this paper.The method has the advantages of mild reaction condition,high yield and good atom economy.Most of the aryl methyl ketones and amines can be successfully converted to their corresponding α-ketoamides with 3 equivalents of oxidant tert-butyl hydroperoxide.The crude product was purified by column chromatography and the product was characterized by 1H NMR,13C NMR.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2016-12-08基金项目:国家自然科学基金(21502036)和海南省自然科学基金团队研究(2016CXTD006)资助项目.通信作者:王 博(1983-),男,山东菏泽人,教授,博士,主要从事有机合成、生物催化方面的研究.E-mail:wborganic@163.com林 常(1982-),男,广东湛江人,讲师,博士,主要从事绿色材料合成研究.E-mail:cl.changlin@yahoo.com
更新日期/Last Update: 1900-01-01