[1]黄阳妃,雷大有,陈 乐,等.2,6-吡啶二甲酰硫脲的合成与除草活性[J].江西师范大学学报(自然科学版),2017,(04):425-428.
　HUANG Yangfei,LEI Dayou,CHEN Le,et al.The Synthesis and Herbicidal Activity of 2,6-Dicarbonyl Thiourea Pyridine Derivatives[J].Journal of Jiangxi Normal University:Natural Science Edition,2017,(04):425-428.
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2,6-吡啶二甲酰硫脲的合成与除草活性()
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《江西师范大学学报》（自然科学版）[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2017年04期
页码:
425-428
栏目:
出版日期:
2017-09-01

文章信息/Info

Title:
The Synthesis and Herbicidal Activity of 2,6-Dicarbonyl Thiourea Pyridine Derivatives
作者:
黄阳妃; 雷大有; 陈 乐; 王 涛; 罗 劲
1.江西师范大学化学化工学院,江西省化学生物学重点实验室,江西 南昌 330022; 2.江西师范大学分析测试中心,江西 南昌 330022
Author(s):
HUANG Yangfei; LEI Dayou; CHEN Le; WANG Tao; LUO Jin
1.Jiangxi Province Key Laboratory of Chemical Biology,College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang Jiangxi 330022,China; 2.Analytical & Testing Center,Jiangxi Normal University,Nanchang Jiangxi 330022,China
关键词:
2; 6-吡啶二甲酰硫脲;  合成;  除草活性
Keywords:
2; 6-dicarbonyl thiourea pyridine;  synthesis;  herbicidal activities
分类号:
O 626.32
文献标志码:
A
摘要:
以2,6-吡啶二甲酸为原料经酰氯化后与KSCN反应生成2,6-吡啶二甲酰异硫氰酸酯,再与芳香胺加成反应合成了10种2,6-吡啶二甲酰硫脲衍生物(4a～4j),其结构均通过1H NMR、LC-MS、IR和元素分析测试进行了表征.初步的生物活性测试结果表明所设计合成的化合物部分具有较好的除草活性.
Abstract:
Ten novel 2,6-dicarbonyl thiourea pyridine derivatives(4a-4j)have been successfully synthesized via the reaction of 2,6-isothiocyanate pyrimidine with aromatic amine.The structures of the target compounds are characterized by LC-MS,IR,1H NMR and elementary analysis.The results of preliminary bioassay indicated that some of these compounds show good herbicidal activities.

参考文献/References:

[1] 薛思佳,卞王东,柴安,等.N-取代芳酰氨基-5-氟代苯基-2-呋喃甲酰硫脲的合成与生物活性测定 [J].有机化学,2008,28(5):865-869.
[2] Lin Qi,Yao Hong,Wei Taibao,et a1.Synthesis and plant growth regulatory activity of o-nitrobenzoyl thiourea derivatives [J].Indian Journal Chemistry,2009,48B(1):124-127.
[3] 刘长春.含2-氯-5-甲基吡啶结构的芳甲酰基硫脲的合成与生物活性 [J].化学试剂,2013,35(2):130-134.
[4] 徐志红,刘斌,王明安,等.新型酰基硫脲及酰基脲的合成及其杀虫活性 [J].有机化学,2014,34(12):2517-2522.
[5] 李付博,万福贤,姜林,等.N-(4,6-二甲基嘧啶-2-基)-N’-
[3-(4-三氟甲基苯基)-5-甲基-异嘌唑-4-基]酰基硫脲的合成及其除草活性 [J].合成化学,2014,22(4):471-474.
[6] Ibrahim M A,Yusof M S M,Nakisah M A.Anti-amoebic properties of carbonyl thiourea derivatives [J].Molecules,2014,19(4):5191-5204.
[7] Wang Baolei,Ma Yi,Xiong Lixia,et al.Synthesis and insecticidal activity of novel N-pyridylpyrazole carbonyl thioureas [J].Chinese Journal of Chemistry,2014,30(4):815-821.
[8] George M N,Constantid D,Mariana C C,et al.Synthesis and antimicrobial screening of N-(1-methyl-1H-pyrazole-4-carbonyl)-thiourea derivatives [J].Med Chem Res,2012,21(3):308-314.
[9] Saeed A,Fl?rke U,Erben M F.A review on the chemistry,coordination,structure and biological properties of 1-(acyl/aroyl)-3-(substituted)thioureas [J].Journal of Sulfur Chemistry,2014,35(3):318-355.
[10] Patujo J,Badshah A,Rauf M K.Synthesis,chemical characterization,DNA interaction and antioxidant,studies of new nitrosubstituted thioureas and their copper complexes [J].Journal of Chinese Chemical Society,2015,62(11):1020-1027.
[11] Xie Yong,Chi Huiwei,Liu Changling.Design,synthesis,and herbicidal activity of novel substituted 3-(pyridin-2-yl)benzenesulfonamide derivatives [J].J Agric Food Chem,2014,62(52):12491-12496.
[12] Koren B,Stanovnik B,Tisler M.Synthesis and chemical reactivity of some 1,2,4- Thiadiazolo
[2,3-a]-pyrimidines and related compounds [J].J Heterocylic Chem,1977,14(4):621-625.
[13] Yoshiaki N,Keiichiro N,Keiichi I.QSAR of larvicidal N-
[5-(substitutedphey1)-1,3,4- thiadiazol-2-y1]-benzamides in the inhibition of N-acetylglucosamine incorporation into a cultured integument system [J].J Pestic Sci,1996,21(2):195-201.
[14] 李刚月,阎圣刚,蒋山,等.含吡啶(噻唑)甲基的哌嗪类化合物的合成及生物活性 [J].有机化学,2008,28(11):2001-2006.
[15] 戴红,刘建兵,苗文科,等.新型含吡啶环取代的吡唑肟醚类化合物的合成及生物活性研究 [J].有机化学,2011,31(10):1662-1667.
[16] 杨曼丽,刘清芝,徐鲁斌.含吡啶环的双酰基硫脲衍生物的合成与生物活性 [J].精细化工中间体,2012,42(1):18-20.
[17] Alvin W Singer,Mcelvain S M.Relative reactivities of certain 2- and 2,6-substituted piperidines [J].J Am Chem Soc,1935,57(6):1136-1137.
[18] 王涛.靶标酶抑制剂的设计、合成与性质研究 [D].武汉:华中师范大学,2004.

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备注/Memo

备注/Memo:
收稿日期:2016-11-15基金项目:国家自然科学基金(21262018,21562026),江西省自然科学基金(20161BAB203085)和江西省自然科学青年基金(20161BAB213072)资助项目.通信作者:王 涛(1962-),男,江西吉安人,教授,博士,博士生导师,主要从事药物(绿色农药)分子设计、合成与化学生物学研究.E-mail:wangtao@jxnu.edu.cn罗 劲(1986-),男,江西吉安人,博士,主要从事新型杂环化合物的合成与生物活性研究.E-mail:jinlu
更新日期/Last Update: 1900-01-01