[1]刘德永,陈金珠*,肖转泉,等.含氢化诺卜基叔胺氢卤酸盐的合成与抑菌活性研究[J].江西师范大学学报(自然科学版),2020,(03):247-252.[doi:10.16357/j.cnki.issn1000-5862.2020.03.06]
　LIU Deyong,CHEN Jinzhu*,XIAO Zhuanquan,et al.The Synthesis and Antibacterial Activity of Hydrohalobyl Tertiary Amine Hydrohalide[J].Journal of Jiangxi Normal University:Natural Science Edition,2020,(03):247-252.[doi:10.16357/j.cnki.issn1000-5862.2020.03.06]
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含氢化诺卜基叔胺氢卤酸盐的合成与抑菌活性研究()
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《江西师范大学学报》（自然科学版）[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2020年03期
页码:
247-252
栏目:
化学与生命科学
出版日期:
2020-06-10

文章信息/Info

Title:
The Synthesis and Antibacterial Activity of Hydrohalobyl Tertiary Amine Hydrohalide
文章编号:
1000-5862(2020)03-0247-06
作者:
刘德永1; 陈金珠2*; 肖转泉3; 范国荣4; 王宗德4
1.江西师范大学国家单糖化学合成工程技术研究中心,江西 南昌 330022; 2.江西农业大学理学院,国家林草局木本香料(华东)工程技术研究中心,江西 南昌 330045; 3.江西师范大学化学化工学院,江西 南昌 330022; 4.江西农业大学林学院,国家林草局木本香料(华东)工程技术研究中心,江西 南昌 330045
Author(s):
LIU Deyong1; CHEN Jinzhu2*; XIAO Zhuanquan3; FAN GuoRong4; WANG Zongde4
1.National Research Center of Monosaccharide Chemical Synthesis Engineering,Jiangxi Normal Univesrity,Nanchang Jiangxi 330022,China; 2.College of Science,East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration,Jiangxi Agricultural University,Nanchang Jiangxi 330045,China; 3.College of Chemistry and Chemical Engineering,Jiangxi Normal Univesrity,Nanchang Jiangxi 330022,China; 4.College of Forestry,East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration,Jiangxi Agricultural University,Nanchang Jiangxi 330045,China
关键词:
氢化诺卜基;  叔胺盐;  合成;  结构分析;  抑菌活性
Keywords:
hydronopol;  tertiary amine salt;  synthesis;  structural analysis;  antifugal activity
分类号:
O 621; TQ 463
DOI:
10.16357/j.cnki.issn1000-5862.2020.03.06
文献标志码:
A
摘要:
以5种含氢化诺卜基的叔胺分别与氯化氢、溴化氢、碘化氢反应,合成了14个氢化诺卜基叔胺的氢卤酸盐:二甲基氢化诺卜基胺盐酸盐(2a)、二甲基氢化诺卜基胺氢溴酸盐(2b)、二甲基氢化诺卜基胺氢碘酸盐(2c)、二乙基氢化诺卜基胺盐酸盐(2d)、二乙基氢化诺卜基胺氢溴酸盐(2e)、二正丙基氢化诺卜基胺盐酸盐(2f)、二正丙基氢化诺卜基胺氢溴酸盐(2g)、二正丙基氢化诺卜基胺氢碘酸盐(2h)、N-氢化诺卜基哌啶盐酸盐(2i)、N-氢化诺卜基哌啶氢溴酸盐(2j)、N-氢化诺卜基哌啶氢碘酸盐(2k)、N-氢化诺卜基吗啉盐酸盐(2l)、N-氢化诺卜基吗啉氢溴酸盐(2m)、N-氢化诺卜基吗啉氢碘酸盐(2n).对所合成的化合物进行了1H NMR、13C NMR和LC-MS分析,表征了它们的结构.采用菌丝生长速率法测试了化合物2a、2b、2f、2h对5种植物病原菌生长的抑制率,结果表明它们均有较好的抑菌活性.当药液质量浓度为500 mg·L-1时,2a、2b、2f、2h对烟草黑胫病菌的抑制率均在83%以上,其中2a的抑制率为100%; 对西瓜枯萎病菌和苦瓜尖孢镰刀病菌的抑制率均在65%以上,部分高达85%; 对轮枝镰刀病菌的抑制率均在75%以上.
Abstract:
Fourteen hydronopyl tertiary amine hydrohalide,namely dimethyl hydronopyl amine hydrochloride(2a),dimethyl hydronopyl amine hydrobromide(2b),dimethyl hydronopyl hydroiodate(2c),diethyl hydronopyl amine hydrochloride(2d),diethyl hydronopyl amine hydrobromide(2e),di-n-propyl hydronopyl amine hydrochloride(2f),di-n-propyl hydronopyl amine hydrobromide(2g),di-n-propyl hydronopyl hydroiodate(2h),N-hydronopyl pyfidine hydrochloride(2i),N-hydronopyl pyfidine hydrobromide(2j),N-hydronopyl pyfidine hydroiodate(2k),N-hydronorpyl morpholine hydrochloride(2l),N-hydronorpyl morpholine hydrobromide(2m),N-hydronorpyl morpholine hydroiodate(2n),are synthesized from five kinds of hydronopyl tertiary amines with hydrogen chloride,hydrogen bromide,and hydrogen iodide respectively.The structures of thefourteen targetcompounds are indentified by 1H NMR,13C NMR and LC-MS analysis.The antifungal activities of four compounds(2a、2b、2f、2h)against Fusarium oxysporum,Colletotrichum acutatum,Fusarium verticillioides,Phytophthora nicotianae var. nicotianae Breda de Haan and Fusarium oxysporumf sp. momordicae are tested by using the mycelial growth rate method,the results show that the four compounds have good antifugal activity.At the mass concentration of 500 mg·L-1.Their inhibition rates against Phytophthora nicotianae var nicotianae Breda de Haan are more than 83%,and the inhibition rate of 2a is 100%.Their inhibition rates against Fusarium oxysporum and Fusarium oxysporumf sp. momordicae are more than 65%(the highest is 85%).Their inhibition rates against Fusarium verticillioides are more than 75%.

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备注/Memo

备注/Memo:
收稿日期:2020-02-14
基金项目:国家自然科学基金(31660178)和江西省重点研发课题(20192ACB60011)资助项目.
通信作者:陈金珠(1973-),男,江西新余人,副教授,主要从事有机化学的教学和科研工作.E-mail:jxnccjz@126.com
更新日期/Last Update: 2020-06-10