[1]冯雪贞,肖转泉,王宗德,等.E型莰烯醛肟、莰烯腈的合成与抑菌活性[J].江西师范大学学报(自然科学版),2020,(02):178-181.[doi:10.16357/j.cnki.issn1000-5862.2020.02.12]
　FENG Xuezhen,XIAO Zhuanquan,WANG Zongde,et al.The Synthesis and Antibacterial Activity of E-Type Camphene Aldoxime and E-Type Camphene Nitrile[J].Journal of Jiangxi Normal University:Natural Science Edition,2020,(02):178-181.[doi:10.16357/j.cnki.issn1000-5862.2020.02.12]
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E型莰烯醛肟、莰烯腈的合成与抑菌活性()
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《江西师范大学学报》（自然科学版）[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2020年02期
页码:
178-181
栏目:
化学与生命科学
出版日期:
2020-04-10

文章信息/Info

Title:
The Synthesis and Antibacterial Activity of E-Type Camphene Aldoxime and E-Type Camphene Nitrile
文章编号:
1000-5862(2020)02-0178-04
作者:
冯雪贞1; 肖转泉2; 王宗德1; 范国荣1; 陈金珠3*
1.江西农业大学林学院,国家林业和草原局木本香料(华东)工程技术研究中心,江西 南昌 330045; 2.江西师范大学化学化工学院,江西 南昌 330022; 3.江西农业大学理学院,江西 南昌 330045
Author(s):
FENG Xuezhen1; XIAO Zhuanquan2; WANG Zongde1; FAN Guorong1; CHEN Jinzhu3*
1.College of Forestry,Jiangxi Agriculture University,East China Woody Fragrance and Flavor Engineering and Technology Research Center of State Forestry and Steppe Administration,Nanchang Jiangxi 330045,China; 2.College of Chemistry,Jiangxi Normal Universi
关键词:
E型莰烯醛;  E型莰烯醛肟;  莰烯腈;  结构分析;  抑菌活性
Keywords:
E-type camphene aldehyde;  E-type camphene aldehyde oxime;  camphene nitrile;  structural analysis;  bacteriostatic activity
分类号:
O 621; TQ 463
DOI:
10.16357/j.cnki.issn1000-5862.2020.02.12
文献标志码:
A
摘要:
将E型莰烯醛与盐酸羟胺在碳酸钠作用下反应合成了E型莰烯醛肟,将E型莰烯醛肟用乙酸酐脱水得到E型莰烯腈,产品得率和纯化均在90%以上.产物结构均经MS和NMR分析方法进行了表征.采用菌丝生长速率法,将E型莰烯醛肟和莰烯腈对12种植物病原真菌的生长进行了抑制活性试验,实验结果表明:在药液质量浓度为500 mg?L-1时,E型莰烯醛肟对油茶炭疽病菌(GlomerellaCingulata,A)、玉米赤霉病菌(Gibberellazeae,B)、梨链格孢菌(Alternariakikuchiana,C)、辣椒菌核病菌(Sclerotiniasclerotiorum,D)、水稻纹枯病菌(Thanatephoruscucumeris,E)、辣椒疫霉病菌(Phytophthoracapsici,F)、毛竹枯梢病菌(Ceratosphaeriaphyllostachydis,G)、猕猴桃果实拟茎点霉(Botryisphariadothide,H)、葡萄炭疽病菌(Colletorichumgloeosporioides,K)的抑制率均达100%; E型莰烯腈对所试植物病原真菌的抑制率均高于98.5%,多数为100%.当药液质量浓度为250 mg?L-1时,E型莰烯醛肟对A、B、E、F、G、H、K等7种植物病原真菌的抑制率仍达95%以上.抑制效果超过甚至远超过百菌清的抑制效果.
Abstract:
E-type camphene aldehyde oxime is synthesized by the reaction of E-type camphene aldehyde with hydroxylamine hydrochloride under the action of sodium carbonate.E-type camphene aldehyde oxime is dehydrated with acetic anhydride to obtain E-type camphene nitrile.The yield and purity of the product are over 90%.The structures of the products are characterized by MS and NMR.The inhibitory activity of E-type camphene aldoxime and camphene nitrile on the growth of 12 plant pathogenic fungi is tested by mycelial growth rate method.The results show that under the concentration of 500 mg?L-1,the inhibition rate of E-camphene aldoxime on GlomerellaCingulata(A),Gibberellazeae(B),Alternariakikuchiana(C),Sclerotiniasclerotiorum(D)and Thanatephoruscucumeris(E),Phytophthoracapsici(F),Ceratosphaeriaphyllostachydis(G),Botryisphariadothide(H),Colletotrichumgloeosporioides(K)all reach 100%.The inhibition rate of E-type camphene nitrile on plant pathogenic fungi is higher than 98.5%,most of which are 100%.When the concentration of the solution is 250 mg?L-1,the inhibition rate of E-camphene aldoxime to 7 plant pathogenic fungi,such as A,B,E,F,G,H,K is still more than 95%.The inhibition rate of 2 compounds exceeds or even far exceeds that of chlorothalonil.

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备注/Memo

备注/Memo:
收稿日期:2019-09-19
基金项目:国家重点研发计划(2017YFD0600704),国家自然科学基金(31660178)和江西省杰出青年人才计划(20162BCB23030)资助项目.
通信作者:陈金珠(1973-),男,江西新余人,副教授,主要从事有机化学及天然产物的研究.E-mail:jxnccjz@126.com
更新日期/Last Update: 2020-04-10