参考文献/References:
[1] Berg H,Purcell E.Physics of chemoreception [J].J Biophy,1977,20(2):193-219.
[2] Berg O.A model for the statistical fluctuations of protein numbers in a microbial population [J].J Theor Biol,1978,71(4):587-603.
[3] Paulsson J.Summing up the noise in gene networks [J].Nature,2004,427(6973):415-418.
[4] Raser J M,Oshea E K.Noise in gene expression:origins,consequences,and control [J].Science,2005,309(5743):2010-2013.
[5] Avigdor Eldar,Michael B,Elowitz.Functional roles for noise in genetic circuits [J].Nature,2010,467(7312):167-173.
[6] Kittisopikul M,Suel G M.Biological role of noise encoded in a genetic network motif [J].Proc Natl Acad Sci USA,2010,107(30):13300-13305.
[7] Kærn M,Elston T C,Blake W J,et al.Stochasticity in gene expression:from theories to phenotypes [J].Nat Rev Gen,2005,6(6):451-464.
[8] Hung Michelle,Chang Emily,Hussein R,et al.Modulating the frequency and bias of stochastic switching to control phenotypic variation [J].Nat Commun,2014,5:4574.
[9] Makeyev E V,Maniayis T.Multilevel regulation of gene expression by microRNAs [J].Science,2008,319(5871):1789-1790.
[10] Hobert O.Gene regulation by transcription factors and microRNAs [J].Science,2008,319(5871):1785-1786.
[11] Miska E A.How microRNAs control cell division,differentiation and death [J].Current Opinion in Genetics & Development,2005,15(5):563-568.
[12] Levine E,Zhang Zhongge,Kuhlman T,et al.Quantitative characteristics of gene regulation by small RNA [J].PLoS Biol,2007,5(9):229.
[13] Shimoni Y,Friedlander G,Hetzroni G,et al.Regulation of gene expression by small non-coding RNAs:a quantitative view [J].Mol Syst Biol,2007,3(1):138.
[14] Shankar Mukherji,Margaret S Ebert,Grace X Y,et al.MicroRNAs can generate thresholds in target gene expression [J].Nature Genetics,2011,43(9):854-859.
[15] Xie Zongru,Yang HsihTe,Liu Weichung,et al.The role of microRNA in the delayed negative feedback regulationof gene expression [J].Biochem Biophys Res Commun,2007,358(3):722-726.
[16] 周天寿.基因表达模型的研究进展:概率分布 [J].江西师范大学学报:自然科学版, 2012,36(3):221-229.
[17] 周天寿.概率主方程的研究综述 [J].江西师范大学学报:自然科学版, 2015,39(1):1-6.
[18] Schmiedel J M,Klemm S L,Zheng Yannan,et al.MicroRNA control of protein expression noise [J].Science,2015,348(6230):128-132.
[19] Vohradsky J,Panek J,Vomastek T.Numerical modelling of microRNA-mediated mRNA decay identifies novel mechanism of microRNA controlled mRNA downregulation [J].Nucleic Acids Research,2010,38(14):4579-4585.
[20] Chen Kevin,Rajewsky N.The evolution of generegulation by transcription factors and microRNAs [J].Nat Rev Genet,2007,8(2):93-103.
[21] Ramachandran V,Chen Xuemei.Degradation of microRNAs by a family of exoribonucleases in arabidopsis [J].Science,2008,321(5895):1490-1492.
[22] Zhang Jiajun,Chen Luonan,Zhou Tianshou.Analytical distribution and tunability of noise in a model of promoter progress [J].Biophys J,2012,102(6):1247-1257.
[23] Shahrezaei V,Swain P S.Analytical distributions for stochastic gene expression [J].Proc Nat Acad Sci USA,2008,105(45):17256-17261.
[24] 雷锦誌.生化反应系统的建模与分析 [J].江西师范大学学报:自然科学版, 2015,39(3):230-239.
[25] Acar M,Mettetal J T,van Oudenaarden A.Stochastic switching as a survival strategy in fluctuating environments [J].Nat Genet,2008,40(4):471-475.
[26] Kussell E,Leibler S.Phenotypic diversity,population growth,and information influctuating environments [J].Science,2005,309(5743):2075-2078.
[27] Ochab-Marcinek A,Tabaka M.Bimodal gene expression in noncooperative regulatory systems [J].Proc Natl Acad Sci USA,2010,107(51):22096-22101.