[1]施昌宏.miRNA调控诱导的随机增益和双峰表达[J].江西师范大学学报(自然科学版),2016,40(01):15-21.
 SHI Changhong.The miRNA Regulation-Induced Random Gain and Bimodal Expression[J].,2016,40(01):15-21.
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miRNA调控诱导的随机增益和双峰表达()
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《江西师范大学学报》(自然科学版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
40
期数:
2016年01期
页码:
15-21
栏目:
出版日期:
2016-01-25

文章信息/Info

Title:
The miRNA Regulation-Induced Random Gain and Bimodal Expression
作者:
施昌宏
广州医科大学公共卫生学院,广东 广州 510275
Author(s):
SHI Changhong
School of Public Health,Guangzhou Medical University,Guangzhou Guangdong 510275,China
关键词:
miRNA 后转录调控 随机增益 双峰表达 基因模型
Keywords:
miRNA post-transcriptional regulation random gain bimodal expression gene model
分类号:
O 242; Q 332
文献标志码:
A
摘要:
一方面,miRNA通过加速mRNA的降解对基因表达进行后转录调控; 另一方面,最新的研究表明某些细胞中miRNA以切换的方式对mRNA进行调控.基于此,建立起一个miRNA后转录调控的基因表达模型.通过对相应化学主方程的分析求解与数值模拟,研究了miRNA调控过程中的噪声对mRNA表达的定量和定性影响.结果显示:这种随机涨落既能提高mRNA的平均表达水平(称这种现象为随机增益)又能诱导mRNA的双峰表达.研究结果表明:miRNA后转录调控是一种有效控制基因表达的机制.
Abstract:
While miRNA often post-transcriptionally regulates gene expression through accelerating the degradation of mRNA,recent studies indicate that miRNA in some cells can regulate the expression of mRNA in a switching manner.Based on this,in this paper a model of gene expression at the transcription level is established,which considers miRNA post-transcriptional regulation of mRNA degradation.By analytical solution to and numerical simulations of the corresponding chemical master equation,the effect of noise in the miRNA regulation process on the mRNA expression is studied both quantitatively and qualitatively.Our analysis shows that this noise can not only raise the expression level of mRNA(such a phenomenon is called as random gain)but also can induce the bimodal expression of mRNA.These results indicate that miRNA post-transcriptional regulation is a mechanism of efficiently controlling gene expression.

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备注/Memo

备注/Memo:
基金项目:广东省自然科学基金(2014A030310181)资助项目.
更新日期/Last Update: 1900-01-01