[1]周 佳,方秋生,余治宇,等.多羟基1,2-二取代苯并咪唑的选择性合成和抗氧化性质研究[J].江西师范大学学报(自然科学版),2017,(04):421-424.
 ZHOU Jia,FANG Qiusheng,YU Zhiyu,et al.The Chemoselective Synthesis of 1,2-Disubstituted Benzoimidazoles and Their Antioxidant Properties for Radical Scavenging[J].Journal of Jiangxi Normal University:Natural Science Edition,2017,(04):421-424.
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多羟基1,2-二取代苯并咪唑的选择性合成和抗氧化性质研究()
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《江西师范大学学报》(自然科学版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2017年04期
页码:
421-424
栏目:
出版日期:
2017-09-01

文章信息/Info

Title:
The Chemoselective Synthesis of 1,2-Disubstituted Benzoimidazoles and Their Antioxidant Properties for Radical Scavenging
作者:
周 佳方秋生余治宇宋智彬
江西师范大学化学化工学院,教育部功能有机小分子重点实验室,江西 南昌 330022
Author(s):
ZHOU JiaFANG QiushengYU ZhiyuSONG Zhibing
College of Chemistry and Chemical Engineering,Key Laboratory of Functional Small Organic Molecule,Ministry of Education,Jiangxi Normal University,Nanchang Jiangxi 330022,China
关键词:
苯并咪唑 抗氧化 自由基清除
Keywords:
benzimidazole antioxidant radicals scavenger
分类号:
O 621.32
文献标志码:
A
摘要:
苯并咪唑衍生物是一类具有多种生理活性的化合物,在医药学中应用广泛.化合物分子中含有羟基会有助于提高其对自由基的清除能力.但是在传统合成路线上,对于羟基等易氧化基团需在合成过程中先对羟基进行保护.采用一步合成实现了多羟基取代的1,2-二取代苯并咪唑类化合物的合成,对合成出的1,2-二取代苯并咪唑类化合物进行了抗自由基活性研究.在ABTS、DPPH自由基清除实验中,多羟基取代的1,2-二取代苯并咪唑都显示出了较好的活性.
Abstract:
Benzoimidazole derivatives are a class of compounds with a variety of physiological activity which are widely used in medicine.The hydroxyl group in the compounds can enhance the biological activities in antioxidation.But hydroxyl group often needs protection in the traditional procedure due to the sensitive to air or oxidant.Herein we report a convenient and efficient method for preparation of 1,2-disubstituted benzoimidazoles without the protection of the hydroxyl group.And the 1,2-disubstituted benzoimidazole with muti hydroxyl group showed good activity at antioxidation and radical scavenging which is confirmed though ABTS and DPPH radical scavenging experiments.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2016-12-19基金项目:江西省自然科学基金(2016BAB213070)和江西省教育厅科技计划(GJJ13214)资助项目.通信作者:宋智彬(1982-),男,江西横峰人,副教授,博士,主要从事功能有机分子合成与应用研究.E-mail:zbsong@jxnu.edu.cn
更新日期/Last Update: 1900-01-01