[1]彭伟梦,黄运红,李瑾,等.炭样小单孢菌JXNU-1产抗生素对G~-的体外抗菌作用及其机理的初步研究[J].江西师范大学学报(自然科学版),2013,(02):162-165.
　PENG Wei-meng,HUANG Yun-hong,LI Jin,et al.Studies on the Antimicrobial Activity and Its Mechanism of an Antibiotic, from Micromonospora carbonacea JXNU-1,Against Gram-Negative Bacteria in Vitro[J].Journal of Jiangxi Normal University:Natural Science Edition,2013,(02):162-165.
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炭样小单孢菌JXNU-1产抗生素对G~-的体外抗菌作用及其机理的初步研究()
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《江西师范大学学报》（自然科学版）[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2013年02期
页码:
162-165
栏目:
出版日期:
2013-03-01

文章信息/Info

Title:
Studies on the Antimicrobial Activity and Its Mechanism of an Antibiotic, from Micromonospora carbonacea JXNU-1,Against Gram-Negative Bacteria in Vitro
作者:
彭伟梦;黄运红;李瑾;高兴强;龙中儿
江西师范大学生命科学学院,江西南昌,330022
Author(s):
PENG Wei-meng；HUANG Yun-hong；LI Jin；GAO Xing-qiang；LONG Zhong-er
关键词:
炭样小单孢菌; 抗生素; 革兰氏阴性菌; 抗菌作用
Keywords:
Micromonospora carbonacea; antibiotics; gram-negative bacteria; antimicrobial activity
分类号:
Q939.9
文献标志码:
A
摘要:
基于土壤中分离到的一株具广谱抗菌活性的炭样小单孢菌JXNU-1,研究了JXNU-1所产抗生素对G-的体外抗菌作用.研究结果表明:炭样小单孢菌JXNU-1所产抗生素对产气肠杆菌、伤寒沙门氏菌、铜绿假单孢菌、福氏志贺氏菌等常见G-细菌均有抗菌作用,其最低杀菌浓度一般是最低抑菌浓度的8 ～16倍.杀菌曲线表明其对G-的杀菌作用非常快速,8h的杀菌率已超过90；.进一步的研究表明抗生素抗G-的作用机理在于抑制细菌蛋白质的合成,进而抑制细胞的分裂.
Abstract:
Based on the strain of Micromonospora carbonacea JXNU-1 with board-spectrum antimicrobial activity,isolated from a soil sample,the antibacterial activity of its antibiotics against gram-negative bacteria in vitro was studied.The results indicated that the antibiotics had antimicrobial activity against common gram-negative bacteria,such as Enterobacter aerogenes,Salmonella typhi,Pseudomonas aeruginosa,Shigella flexneri and so on.The killing curve proved that the bactericidal action was very rapidly,the sterilizing rate over 90% when germs were treated with antibiotics for 8 hours,and the MBC usually 8 to 16 times of the MIC.Further more,studies have shown that the mechanism of the antibiotics against gram-negeative bacteria is to inhibit bacterial protein synthesis,and thereby inhibiting cell division.

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备注/Memo

备注/Memo:
国家自然科学基金(31160029)；江西省自然科学基金(20122BAB204008)
更新日期/Last Update: 1900-01-01