[1]徐丽锋,肖转泉,王鹏,等.氢化诺卜醛环状缩醛类化合物的合成及其抑菌活性[J].江西师范大学学报(自然科学版),2014,(05):472-475.
　XU Li-feng,XIAO Zhuan-quan,WANG Peng,et al.The Synthesis and Antifungal Activity of Cyclic Acetal Hydronopic Aldehyde Derivatives[J].Journal of Jiangxi Normal University:Natural Science Edition,2014,(05):472-475.
点击复制

氢化诺卜醛环状缩醛类化合物的合成及其抑菌活性()
分享到：

《江西师范大学学报》（自然科学版）[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2014年05期
页码:
472-475
栏目:
出版日期:
2014-10-31

文章信息/Info

Title:
The Synthesis and Antifungal Activity of Cyclic Acetal Hydronopic Aldehyde Derivatives
作者:
徐丽锋;肖转泉;王鹏;范国荣;陈金珠;陈尚钘;王宗德
江西农业大学林学院,江西 南昌,330045；江西师范大学化学化工学院,江西 南昌,330027
Author(s):
XU Li-feng；XIAO Zhuan-quan；WANG Peng；FAN Guo-rong；CHEN Jin-zhu；CHEN Shang-xing；WANG Zong-de
关键词:
氢化诺卜醇; 环状缩醛; 合成; 抑菌活性
Keywords:
hydronopol; cyclic acetal; synthesis; fungicidal activity
分类号:
TQ463
文献标志码:
A
摘要:
以氢化诺卜醇为原料，经氯铬酸吡啶（PCC）氧化合成氢化诺卜醛，再由氢化诺卜醛与乙二醇、1，2-丙二醇和1，3-丙二醇分别发生缩合反应，合成了氢化诺卜醛乙二醇缩醛（2a）、氢化诺卜醛1，2-丙二醇缩醛（2b）、氢化诺卜醛1，3-丙二醇缩醛（2c），其结构经 FT-IR、EI-MS、1 H NMR、13 C NMR 确认，3种化合物均为新化合物.以枇杷炭疽病菌（Cdletotrichum gloeosporioides）、油茶炭疽病菌（ Colletotrichum gloeospori-oides）、辣椒疫病菌（Phytophthora capsici）、水稻纹枯病菌（hizocitonia solani）、水稻稻瘟病菌（Magnaporthe grisea）、莴苣菌核病菌（Sclerotinia sclerotiorum）为实验对象，开展抑菌活性测定，结果表明：在100 mg·L -1浓度下，3种化合物对6种病原菌均具有一定的抑菌活性，化合物2c 对辣椒疫病菌抑菌率达到100；，化合物2b 对水稻纹枯病菌抑菌率达到98.78；，化合物2a 和2c 对油茶炭疽病菌、2b 对莴苣菌核、2c 对水稻纹枯病菌的抑菌率均在80；以上.
Abstract:
The hydronopic aldehyde was synthesized from hydronopol via pyridinium chlorochromate(PCC)oxida-tion. Then the hydronopic aldehyde reacted with aldehyde,glycol,1,2-propanediol and 1,3-propanediol cyclic. Finally,three new derivatives,hydronopic aldehyde 1,2-ethandiol acetal(2a),hydronopic aldehyde 1,2-propanediol acetal(2b),hydronopic aldehyde 1,3-propanediol acetal(2c)were synthesized. The structures of all compounds were confirmed by IR,ESI-MS,1 H NMR and 13 C NMR. The compounds were used of carrying out preliminary bioas-say tests,and the Cdletotrichum gloeosporioides,Colletotrichum gloeosporioides,Phytophthora capsici,Rhizocitonia so-lani,Magnaporthe grisea and Sclerotinia sclerotiorum as the experimental subject. Antifungal activity showed that all the compounds exhibit some fungicidal activity against six fungi tested at the concentration of 100 mg·L - 1 ,among them,2a showed 100； inhibition rate against Phytophthora capsici,the inhibition rate of 2b against Rhizoctorzia so-lani were 98. 78； ,the inhibition rate of 2a and 2c against Colletotrichum gloeosporioides,2b against Sclerotinia scle-rotiorum,2c against Rhizoctorzia solani were above 80； .

参考文献/References:

[1] Slaton N A,Cartwright R D,Meng J,et a1.Sheath blight severity and rice yield as affected by nitrogen fertilizer rate,application method and fungicide [J].Agronomy Journal,2003,95(6):1489-1496.
[2] Spotts R A,Cervantes L A.Populations,pathogenicity and benomyl resistance of Botrytis spp.,Penicillium spp.and Mucor pirformis in packing houses:US,8628872 [P].1986.
[3] 郑爱萍,李平,王世全,等.水稻纹枯病菌拮抗菌B3的分离与鉴定及杀菌蛋白的获得 [J].中国水稻科学,2002,16(4):356-360.
[4] Kolicheski M B,Cocco L C,Mitchell D A,et al.Synthesis of myrcene by pyrolysis of β-pinene:analysis of decomposition reaction [J].Journal of Analytical and Applied Pyrolysis,2007,80(1):92-100.
[5] 肖转泉,刘群芳,傅艳艳,等.由β-蒎烯合成诺卜醇的反应研究 [J].精细化工,1999,16(增刊):354-356.
[6] 韩招久,王宗德,姜志宽,等.桥环萜类化合物的合成及其对蚂蚁驱避活性的研究 [J].江西农业大学学报:自然科学版,2008,30(4):586-591.
[7] 韩招久,王宗德,姜志宽,等.萜类化合物对小菜蛾幼虫的拒食活性 [J].昆虫知识,2007,44(6):863-867.
[8] 韩招久,郑卫青,姜志宽,等.萜类蚜虫拒食剂的筛选研究 [J].江西农业大学学报:自然科学版,2010,32(1):78-84.
[9] Wang Zongde,Song Jie,Chen Jinzhu,et al.QSAR study of mosquito repellents from terpenoid with a six-member-ring [J].Bioorg Med Chem Lett,2008,18(9):2854-2859.
[10] 王宗德,陈金珠,宋湛谦,等.羟基香茅醛缩醛类化合物的合成及对蚊虫的驱避活性 [J].昆虫学报,2010,53(11):1241-1247.
[11] 刘燕,肖转泉,卢平英,等.氢化诺卜基甲酰胺类化合物的合成与结构表征 [J].江西师范大学学报:自然科学版,2013,37(5):515-518.
[12] 戴桂馥,徐海伟,王俊峰,等.穿心莲内酯3,19-缩醛(酮)衍生物对小鼠脾淋巴细胞增殖活性的影响 [J].中国新药杂志,2007,16(5):378-381.
[13] 李正名,黄震年.α-(1,2,4-三唑-1-基)-α-苯甲酸基烯酮N,S; N,N; N,O和O,S-缩醛的合成及生物活性研究 [J].高等学校化学学报,1995,16(12):1874-1877.
[14] 伊廷欣,姜志宽,陈金珠,等.羟基香茅醛-1,2-丙二醇缩醛的驱蚊活性研究 [J].中华卫生杀虫药械,2010,16(2):120-122.

相似文献/References:

[1]陈金珠,肖转泉,徐丽锋,等.含氢化诺卜基的叔胺类化合物的合成与结构分析[J].江西师范大学学报(自然科学版),2016,40(02):179.
　CHEN Jinzhu,XIAO Zhuanquan,XU Lifeng,et al.The Synthesis and Structural Analysis of Hydronopyl Tertiary Amine Compounds[J].Journal of Jiangxi Normal University:Natural Science Edition,2016,40(05):179.

备注/Memo

备注/Memo:
国家林业公益性行业科研专项经费(201304602)；国家自然科学基金(31360163)；江西省主要学科学术和技术带头人培养计划(20133BCB22004)
更新日期/Last Update: 1900-01-01