[1]彭 云,昌家宇,肖转泉,等.十亚甲基-1,10-双(氢化诺卜基二甲基溴化铵)的合成及对9种病菌的抑菌活性[J].江西师范大学学报(自然科学版),2021,(02):159-161+210.[doi:10.16357/j.cnki.issn1000-5862.2021.02.08]
　PENG Yun,CHANG Jiayu,XIAO Zhuanquan,et al.The Synthesis of Dimethyl-1,10-Bis(Hydrogenated Nobuteryl Dimethyl Ammonium Bromide)and Its Antibacterial Activity Against 9 Kinds of Pathogens[J].Journal of Jiangxi Normal University:Natural Science Edition,2021,(02):159-161+210.[doi:10.16357/j.cnki.issn1000-5862.2021.02.08]
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十亚甲基-1,10-双(氢化诺卜基二甲基溴化铵)的合成及对9种病菌的抑菌活性()
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《江西师范大学学报》（自然科学版）[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2021年02期
页码:
159-161+210
栏目:
化学
出版日期:
2021-04-10

文章信息/Info

Title:
The Synthesis of Dimethyl-1,10-Bis(Hydrogenated Nobuteryl Dimethyl Ammonium Bromide)and Its Antibacterial Activity Against 9 Kinds of Pathogens
文章编号:
1000-5862(2021)02-0159-03
作者:
彭 云1; 2; 昌家宇1; 2; 肖转泉3; 王宗德1; 2*
1.江西农业大学林学院,江西 南昌 330045; 2.国家林业草原局木本香料(华东)工程技术研究中心,江西 南昌 330045; 3.江西师范大学化学化工学院,江西 南昌 330027
Author(s):
PENG Yun1; 2; CHANG Jiayu1; 2; XIAO Zhuanquan3;  WANG Zongde1; 2*
1.College of Forestry,Jiangxi Agriculture University,Nanchang Jiangxi 330045,China; 2.East China Woody Fragrance and Flavvor Engineering Technology Research Center,National Forestry and Grassland Administration,Nanchang Jiangxi 330045,China; 3.College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang Jiangxi 330027,China
关键词:
氢化诺卜基;  季铵盐;  合成;  结构表征;  抑菌活性
Keywords:
hydronopol;  quaternary ammonium salt;  synthesis;  structural characterization;  antibacterial activity
分类号:
TQ 35
DOI:
10.16357/j.cnki.issn1000-5862.2021.02.08
文献标志码:
A
摘要:
由含氢化诺卜基的叔胺N,N-二甲基氢化诺卜基胺与1,10-二溴癸烷反应合成得到一个双子季铵盐:十亚甲基-1,10-双(氢化诺卜基二甲基溴化铵).用质谱和核磁共振分析(氢谱与碳谱)表征了合成产物的结构; 采用菌丝生长速率法在5种质量浓度下测试了合成产物对9种植物病原菌的抑菌活性.结果表明:合成的化合物对9种植物病原菌均具有较好的抑制活性,其远高于阳性对照物百菌清.其中对松枯梢病病原菌(Diplodia pinea)、烟草黑胫病菌(phytophthora parasitica var. nicotianae)的抑制率最高,在质量浓度分别为200.0、100.0、50.0、25.0、12.5 mg·L-1的条件下,均为100%; 当质量浓度大于等于50.0 mg·L-1时,对七叶树壳梭孢菌(Fusicoccum aeculi)、水稻纹枯病菌(Rhizoctonia solani)和西瓜枯萎病菌(Fusarium oxyporum f. sp. niveum)的抑制率均为100%.
Abstract:
The gemini quaternary ammonium salt named as decylidene-1,10-bis(hydronopol dimethyl ammonium bromide)is prepared by the reaction of N,N-dimethyl hydronopol amine with 1,10-dibromodecane.The structures of the products are characterized by GC-MS and NMR(1H NMR and 13C NMR),and the antifungal activities of 9 plant pathogens are tested by mycelial growth rate method at 5 concentrations.The results show that the compound have good inhibitory activity against 9 kinds of plant pathogenic bacteria,which is much higher than chlorothalonil.Among them,the highest inhibition rate of Diplodia pinea and phytophthora parasitica var. nicotianae is 100% at the concentrations of 200.0、100.0、50.0、25.0、12.5 mg·L-1.And above 50.0 mg·L-1,the inhibition rate of Fusicoccum aeculi,Rhizoctonia solani and Fusarium oxyporum f. sp. niveum are also 100%.

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备注/Memo

备注/Memo:
收稿日期:2020-06-22
基金项目:国家重点研发计划(2017YFD0600704),国家自然科学基金(31660178,31960295)和江西农业大学研究生创新创业专项资金(YC2020-S235)资助项目.
通信作者:王宗德(1971—),男,江西吉安人,教授,博士,博士生导师,主要从事林产化工研究.E-mail:zongdewang@163.com
更新日期/Last Update: 2021-04-10