[1]裴启明,周祎凡,蒋 龙.从稳定性角度看细菌群落的噪声特性[J].江西师范大学学报(自然科学版),2022,(03):308-313.[doi:10.16357/j.cnki.issn1000-5862.2022.03.14]
 PEI Qiming,ZHOU Yifan,JIANG Long.The Noise Characteristics in Bacterial Communities from the Perspective of Stability[J].Journal of Jiangxi Normal University:Natural Science Edition,2022,(03):308-313.[doi:10.16357/j.cnki.issn1000-5862.2022.03.14]
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从稳定性角度看细菌群落的噪声特性()
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《江西师范大学学报》(自然科学版)[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2022年03期
页码:
308-313
栏目:
信息科学与技术
出版日期:
2022-05-25

文章信息/Info

Title:
The Noise Characteristics in Bacterial Communities from the Perspective of Stability
文章编号:
1000-5862(2022)03-0308-06
作者:
裴启明周祎凡蒋 龙
长江大学物理与光电工程学院,湖北 荆州 434023
Author(s):
PEI QimingZHOU YifanJIANG Long
School of Physics and Optoelectronic Engineering,Yangtze University,Jingzhou Hubei 434023,China
关键词:
持留细胞 反复感染 稳定性因子 噪声
Keywords:
persistent cells recurrent infection stability factor noise
分类号:
Q 612; O 415
DOI:
10.16357/j.cnki.issn1000-5862.2022.03.14
文献标志码:
A
摘要:
在细菌群落中,正常细胞可以转化为持留细胞,从而增加反复感染的风险.在定量生物学中,将细胞个数的相对涨落称为噪声.为了既维持细胞平衡态的稳定性又避免感染反复,该文基于稳定性因子研究了在细菌群落中细胞的噪声特性.研究结果表明:当稳定性因子达到某阈值时,这2种细胞的噪声相互交换并迅速超越强关联区,使得持留细胞的噪声远大于正常细胞的噪声,导致持留细胞几乎完全被正常细胞消除,感染被治愈; 稳定性因子的值越大,这2种细胞的平衡态越稳定,每个细胞相对越独立,感染越容易被治愈.该结果可为临床上治疗反复感染提供理论解决方案.
Abstract:
In bacterial communities,normal cells(NCs)can transform into persistent cells(PCs),thereby increasing the risk of recurringinfections.In quantitative biology,the relative fluctuation in cell numbers is called noise.In order to maintain the stability of cell equilibrium and avoid recurrent infections,the noise characteristics in bacterial communities are studied based on the stability factor.When the stability factor reaches a certain threshold,the noises of the two phenotypes exchange with each other and quickly exceed the strong correlation region,resulting in the noise of PCs being much larger than that of NCs,so that PCs are almost completely eliminatedby NCs,and the infection is cured.The larger the value of the stability factor is,the more stable the equilibrium state of the two phenotypes is,the more independent each phenotype is,and the easier the infection is to be cured.The results may provide a theoretical solution for the clinical treatment of recurrent infections.

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备注/Memo

备注/Memo:
收稿日期:2021-11-23
基金项目:国家自然科学基金(11605014)资助项目.
作者简介:裴启明(1977—),女,湖北松滋人,副教授,博士,主要从事理论生物物理的教学与研究工作.E-mail:qmpei@yangtzeu.edu.cn
更新日期/Last Update: 2022-05-25