[1]刘 怀,叶向荣,过七根,等.旱莲皂苷的溶血活性及构效关系研究[J].江西师范大学学报(自然科学版),2023,(06):594-598.[doi:10.16357/j.cnki.issn1000-5862.2023.06.06]
　LIU Huai,YE Xiangrong,GUO Qigen,et al.The Study on Hemolytic Activities and Structure-Activity Relationships of Eclalbasaponins from Eclipta alba[J].Journal of Jiangxi Normal University:Natural Science Edition,2023,(06):594-598.[doi:10.16357/j.cnki.issn1000-5862.2023.06.06]
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旱莲皂苷的溶血活性及构效关系研究()
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《江西师范大学学报》（自然科学版）[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2023年06期
页码:
594-598
栏目:
化学
出版日期:
2023-11-25

文章信息/Info

Title:
The Study on Hemolytic Activities and Structure-Activity Relationships of Eclalbasaponins from Eclipta alba
文章编号:
1000-5862(2023)06-0594-05
作者:
刘 怀1;  叶向荣1;  过七根2;  张炳火2*
(1.九江学院附属医院,江西 九江 300201; 2.九江学院药学与生命科学学院,江西 九江 332005)
Author(s):
LIU Huai1; YE Xiangrong1; GUO Qigen2; ZHANG Binghuo2*
(1.Affiliated Hospital,Jiujiang University,Jiujiang Jiangxi 332001,China; 2.College of Pharmacy and Life Sciences,Jiujiang University,Jiujiang Jiangxi 332005,China)
关键词:
旱莲草;  旱莲皂苷;  溶血活性;  构效关系
Keywords:
Eclipta alba;  eclalbasaponins;  hemolytic activity;  structure-activity relationships
分类号:
Q 946
DOI:
10.16357/j.cnki.issn1000-5862.2023.06.06
文献标志码:
A
摘要:
从旱莲草中分离到7个单体化合物,经波谱数据分析,鉴定为旱莲皂苷eclalbasaponinsⅠ～Ⅵ(缩写为E-Ⅰ～E-Ⅵ)和β-香树素,其中E-Ⅰ～E-Ⅴ有溶血活性,活性强弱依次为E-Ⅱ>E-Ⅳ>E-Ⅴ>E-Ⅰ>E-Ⅲ.构效关系分析结果表明:C-28位的游离羧基对旱莲皂苷的溶血活性强弱至关重要,C-3位葡萄糖基的数量或硫酸酯化对其溶血活性也有影响.
Abstract:
Seven compounds are isolated from Eclipta alba.These compounds are identified as eclalbasaponins Ⅰ～Ⅵ(abbreviated for E-Ⅰ～E-Ⅵ)and β-amyrin based on the spectral data.Five compounds,namely E-Ⅰ～E-Ⅴ,show hemolytic activities that the decreasing order is E-Ⅱ>E-Ⅳ>E-Ⅴ>E-Ⅰ>E-Ⅲ.Analysis of structure-activity relationships indicates that free carboxyl at C-28 plays a crucial role in the hemolytic activities of eclalbasaponins.Both the amount and the sulfation of the glucosyl at C-3 also influence the hemolytic activities of eclalbasaponins.

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相似文献/References:

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备注/Memo

备注/Memo:
收稿日期:2023-04-28
基金项目:国家自然科学基金(31660096)资助项目.
作者简介:刘 怀(1965—),男,江西九江人,副主任技师,主要从事临床医学检验工作.E-mail: 80544331@qq.com
通信作者:张炳火(1968—),男,江西九江人,教授,博士,主要从事天然产物开发与研究.E-mail: binghuozh@126.com
更新日期/Last Update: 2023-11-25