[1]杨喜艳,张家军*.分子记忆对基因表达过程中的能量消耗影响[J].江西师范大学学报(自然科学版),2020,(02):215-220.[doi:10.16357/j.cnki.issn1000-5862.2020.02.19]
　YANG Xiyan,ZHANG Jiajun*.The Influence of Molecular Memor on Energy Consumption in Gene Expression[J].Journal of Jiangxi Normal University:Natural Science Edition,2020,(02):215-220.[doi:10.16357/j.cnki.issn1000-5862.2020.02.19]
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分子记忆对基因表达过程中的能量消耗影响()
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《江西师范大学学报》（自然科学版）[ISSN:1006-6977/CN:61-1281/TN]

卷:
期数:
2020年02期
页码:
215-220
栏目:
数学与应用数学
出版日期:
2020-04-10

文章信息/Info

Title:
The Influence of Molecular Memor on Energy Consumption in Gene Expression
文章编号:
1000-5862(2020)02-0215-06
作者:
杨喜艳1; 张家军2*
1.广东金融学院金融数学与统计学院,广东 广州 510521; 2.中山大学数学学院,广东 广州 510275
Author(s):
YANG Xiyan1; ZHANG Jiajun2*
1.School of Financial Mathematics and Statistics,Guangdong University of Finance,Guangzhou Guangdong 510521,China; 2.School of Mathematics,SunYat-Sen University,Guangzhou Guangdong 510275,China
关键词:
分子记忆;  基因表达;  能量消耗;  极小势
Keywords:
molecular memory;  gene expression;  energy consumption;  potential minimum
分类号:
O 242; Q 141; Q 332
DOI:
10.16357/j.cnki.issn1000-5862.2020.02.19
文献标志码:
A
摘要:
一方面,分子记忆广泛存在于基因表达过程中; 另一方面,由热动力学的观点,基因表达过程必然消耗能量.这引起一个未探索的问题:分子记忆如何影响基因表达的能量消耗.由此,通过分析一个代表性的、带记忆的基因表达模型,结果发现:分子记忆越强,基因表达消耗越多能量; 极小势和能量消耗之间存在反比例关系,这表明基因表达越稳定,需要消耗的能量越多.这些结果表明分子记忆是一个不可忽略的因素,它能有意义地影响基因表达过程中的能量消耗.
Abstract:
On one hand,molecular memory exists extensively in gene expression.On the other hand,gene expression necessarily consumes energy from the viewpoint of thermodynamics.This raises an unexplored issue how molecular memory affects energy consumption in gene expression.By analyzing a representative stochastic model of gene expression with molecular memory,it is found that the stronger is the molecular memory,the more is the energy consumed.In addition,it is found that there is an inverse relationship between potential minimum and energy consumption,implying that more stable gene expression needs more energy consumption.These results indicate that molecular memory is an unneglectable factor and can significantly impact energy consumption in gene expression.

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备注/Memo

备注/Memo:
收稿日期:2019-08-05
基金项目:国家自然科学基金(11601094,11631005,11475273,11775314),广州市科技基金(201707010117),广东省自然科学基金(2018A0303130120)和广东省教育科学规划课题(2018GXJK119)资助项目.
通信作者:张家军(1978-),男,湖北麻城人,副教授,博士,博士生导师,主要从事计算系统生物学的研究.E-mail:zhjiajun@mail.sysu.edu.cn
更新日期/Last Update: 2020-04-10